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  • Melinda Murphy

Thousands volunteer to take trial vaccine

Updated: May 29, 2020

As scientists around the world race to develop an effective vaccine for COVID-19, thousands of young people have volunteered to willingly contract the virus in order to accelerate the research process.

The “1 Day Sooner” campaign is an initiative that is rallying for healthy, low-risk adults to participate in a “human challenge trial” (HCT) for developing a novel coronavirus vaccine.

Typical medical trials test the safety and efficacy of a vaccine by administering the treatment to several thousand people and comparing the outcomes to a control group of patients who have not received the treatment.

“In these traditional trials, after receiving the treatment, participants return to their homes and their normal daily lives so as to test the treatment under real world conditions,” reads the 1 Day Sooner website. “Since only a small proportion of these participants may encounter the disease, it may take a large number of participants and a good deal of time for these trials to reveal differences between the vaccine and placebo groups.”

An HCT trial, on the other hand, could only require 100 participants to willingly contract the infection so that researchers can immediately begin to test the vaccine’s efficacy. In the past, HCT trials have been conducted on treatments for typhoid fever, cholera, smallpox, dengue, and Zika.

Although a coronavirus HCT would obviously come with its own risks, there are a few ways that researchers can minimize the dangers of the trial. For starters, the trial would likely only recruit volunteers between the ages of 20 to 45 who have no underlying health risks. Volunteers would also probably be adults with a high risk of contracting the virus outside of the trial anyway.

“Finally, study participants would be isolated in highly controlled environments under constant observation,” reads the campaign website. “If infection is detected, they would be provided with excellent medical treatment. Hopefully, pharmaceutical treatments will also be available by the time a study is conducted.”

Adults who have signed up as volunteers for the 1 Day Sooner campaign are not currently bound to any legal obligation to follow through on their offer—but the initiative has already been flooded with support. Since 1 Day Sooner began searching for potential volunteers, almost 24,000 adults across 102 countries have expressed interested in an HCT trial.

The 1 Day Sooner campaign was aptly named because of statistical models estimating that accelerating a vaccine’s approval by one day could save as many as 7,120 lives; speeding up development by three months could save as many as half a million.

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